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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1909 3
1912 1
1913 1
1919 2
1920 1
1922 2
1923 1
1924 1
1925 1
1927 3
1928 1
1929 1
1930 5
1932 4
1933 3
1935 1
1936 4
1937 1
1938 2
1940 2
1941 1
1942 2
1943 1
1944 3
1945 2
1946 3
1947 1
1948 4
1949 1
1950 2
1951 3
1952 4
1953 4
1954 7
1955 2
1956 9
1957 6
1958 5
1959 7
1960 8
1961 10
1962 17
1963 5
1964 11
1965 22
1966 15
1967 28
1968 21
1969 34
1970 38
1971 48
1972 46
1973 55
1974 66
1975 360
1976 394
1977 328
1978 364
1979 398
1980 434
1981 467
1982 526
1983 700
1984 820
1985 909
1986 1000
1987 1017
1988 1118
1989 1394
1990 1516
1991 1617
1992 1759
1993 1877
1994 1958
1995 2265
1996 2437
1997 2639
1998 2679
1999 2891
2000 3164
2001 3381
2002 3756
2003 4034
2004 4637
2005 5214
2006 5633
2007 6206
2008 6653
2009 7120
2010 8056
2011 8938
2012 10006
2013 10762
2014 11525
2015 12569
2016 12982
2017 13892
2018 14990
2019 16439
2020 19238
2021 21648
2022 23760
2023 24484
2024 10593

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Search Results

273,329 results

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Page 1
Targeting AKT for cancer therapy.
Shariati M, Meric-Bernstam F. Shariati M, et al. Expert Opin Investig Drugs. 2019 Nov;28(11):977-988. doi: 10.1080/13543784.2019.1676726. Epub 2019 Oct 12. Expert Opin Investig Drugs. 2019. PMID: 31594388 Free PMC article. Review.
We also explore the efficacy of AKT inhibitors as monotherapies and in combination with cytotoxic and other targeted therapies.Expert opinion: The complex mechanism following AKT inhibition requires the addition of other therapies to prevent resistance and improve c …
We also explore the efficacy of AKT inhibitors as monotherapies and in combination with cytotoxic and other targeted therapies.Expert …
Serotonin toxicity of serotonergic psychedelics.
Malcolm B, Thomas K. Malcolm B, et al. Psychopharmacology (Berl). 2022 Jun;239(6):1881-1891. doi: 10.1007/s00213-021-05876-x. Epub 2021 Jul 12. Psychopharmacology (Berl). 2022. PMID: 34251464 Review.
RESULTS: True ST typically occurs with a serotonergic drug overdose or in combinations in which a drug that can increase intrasynaptic serotonin is combined with a monoamine oxidase inhibitor (MAOI). ...CONCLUSIONS: Serotonin-related adverse reactions exist along a …
RESULTS: True ST typically occurs with a serotonergic drug overdose or in combinations in which a drug that can increase intrasynapti …
Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors.
Heinhuis KM, Ros W, Kok M, Steeghs N, Beijnen JH, Schellens JHM. Heinhuis KM, et al. Ann Oncol. 2019 Feb 1;30(2):219-235. doi: 10.1093/annonc/mdy551. Ann Oncol. 2019. PMID: 30608567 Free article. Review.
Chemotherapy, that was originally thought to be solely immunosuppressive, can exert immunomodulatory effects which may be beneficial in combination with immunotherapy. Each chemotherapeutic drug impacts the tumor microenvironment differently, and in order to determine the …
Chemotherapy, that was originally thought to be solely immunosuppressive, can exert immunomodulatory effects which may be beneficial in c …
Immune Checkpoint Inhibitors Combined with Targeted Therapy: The Recent Advances and Future Potentials.
Li B, Jin J, Guo D, Tao Z, Hu X. Li B, et al. Cancers (Basel). 2023 May 22;15(10):2858. doi: 10.3390/cancers15102858. Cancers (Basel). 2023. PMID: 37345194 Free PMC article. Review.
However, not all combinations of ICIs and targeted therapy work. Combining ICIs with EGFR inhibitors in non-small-cell lung cancer (NSCLC) with EGFR mutations only triggered toxicities and did not improve efficacy. ...We discussed the underlying mechanisms, c …
However, not all combinations of ICIs and targeted therapy work. Combining ICIs with EGFR inhibitors in non-small-cell lung ca …
Radiotherapy-induced ferroptosis for cancer treatment.
Beretta GL, Zaffaroni N. Beretta GL, et al. Front Mol Biosci. 2023 Jun 14;10:1216733. doi: 10.3389/fmolb.2023.1216733. eCollection 2023. Front Mol Biosci. 2023. PMID: 37388241 Free PMC article. Review.
Ferroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive oxygen species metabolisms, which is very relevant for cancer therapy. ...Here, we briefly overview the mechanisms of ferroptosis and the cross-talk existing between the cell …
Ferroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive oxygen species metabolisms, which is very …
When Combined with Pentamidine, Originally Ineffective Linezolid Becomes Active in Carbapenem-Resistant Enterobacteriaceae.
Tang M, Qian C, Zhang X, Liu Y, Pan W, Yao Z, Zeng W, Xu C, Zhou T. Tang M, et al. Microbiol Spectr. 2023 Jun 15;11(3):e0313822. doi: 10.1128/spectrum.03138-22. Epub 2023 May 1. Microbiol Spectr. 2023. PMID: 37125928 Free PMC article.
This study explored the synergistic antibacterial, antibiofilm activities as well as the in vivo efficacy against CRE of pentamidine combined with linezolid. This study further revealed the possible mechanisms underlying the synergy of the combination. ...In …
This study explored the synergistic antibacterial, antibiofilm activities as well as the in vivo efficacy against CRE of pentamidine comb …
Multi-functional polymeric micelles for chemotherapy-based combined cancer therapy.
Bholakant R, Dong B, Zhou X, Huang X, Zhao C, Huang D, Zhong Y, Qian H, Chen W, Feijen J. Bholakant R, et al. J Mater Chem B. 2021 Nov 3;9(42):8718-8738. doi: 10.1039/d1tb01771c. J Mater Chem B. 2021. PMID: 34635905 Review.
In light of intricate tumor structures and distinct tumor microenvironments (TMEs), combinational therapeutic strategies with multiple anticancer drugs from different mechanisms can synergistically optimize the outcomes and concomitantly minimize the adverse effects …
In light of intricate tumor structures and distinct tumor microenvironments (TMEs), combinational therapeutic strategies with multipl …
Combinations Therapies.
Reinmuth N, Reck M. Reinmuth N, et al. Prog Tumor Res. 2015;42:79-94. doi: 10.1159/000437186. Epub 2015 Sep 4. Prog Tumor Res. 2015. PMID: 26384009 Review.
The rationale typically involves different but complementary mechanisms of action, eventually impinging on more than one immune system mechanism. ...Animal models suggest that immunotherapies in combination with these various options offer evidence for synerg …
The rationale typically involves different but complementary mechanisms of action, eventually impinging on more than one immune syste …
Nanoparticle-Based Combination Therapy for Ovarian Cancer.
Wu Y, Yang Y, Lv X, Gao M, Gong X, Yao Q, Liu Y. Wu Y, et al. Int J Nanomedicine. 2023 Apr 12;18:1965-1987. doi: 10.2147/IJN.S394383. eCollection 2023. Int J Nanomedicine. 2023. PMID: 37077941 Free PMC article. Review.
However, the benefits of combination therapy are often compromised. In chemo and chemo/gene combinations, co-deposition of the combined therapeutics in the tumor cells is required, which is difficult to achieve due to dramatic pharmacokinetic differences betw …
However, the benefits of combination therapy are often compromised. In chemo and chemo/gene combinations, co-deposition of the …
Synergistic anti-inflammatory effects and mechanisms of combined phytochemicals.
Zhang L, Virgous C, Si H. Zhang L, et al. J Nutr Biochem. 2019 Jul;69:19-30. doi: 10.1016/j.jnutbio.2019.03.009. Epub 2019 Mar 31. J Nutr Biochem. 2019. PMID: 31048206 Review.
While increasing combinations of phytochemicals on anti-inflammation studies have been reported, there is no report dedicating why combining two or more phytochemicals synergistically attenuates chronic inflammation. In the present review, we summarized different ty …
While increasing combinations of phytochemicals on anti-inflammation studies have been reported, there is no report dedicating why …
273,329 results
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